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. 1998 Apr 20;187(8):1355–1360. doi: 10.1084/jem.187.8.1355

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Inhibition of BCR-mediated cell activation by FcγRIIB– PIR-B. (A) Calcium mobilization stimulated by BCR cross-linking (solid line) and coligation of BCR to FcγRIIB–PIR-B (dashed line) in IIA1.6 cells expressing wild-type FcγRIIB–PIR-B. Calcium release from intracellular calcium store was measured in the presence of 1 mM EGTA, shown by right panel. Histogram in the inset box indicates the expression level of FcγRIIB–PIR-B by 2.4G2 staining. Unstained cells were used as a negative control (open histogram). Stimulation of FcγRIIB–PIR-B alone by 2.4G2 did not induce calcium mobilization. (B) NF-AT activation by BCR cross-linking and the coligation of BCR to FcγRIIB–PIR-B. The results are shown as relative NF-AT activity to BCR cross-linking alone.