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Downregulation of CCR5 on lymphocytes (open symbols) and monocytes (solid symbols). PBMCs were incubated with various concentrations of RANTES (circles) and AOP-RANTES (squares) for 30 min at 37°C, labeled with a monoclonal CCR5 antibody (MC-1), and analyzed as described. It is noteworthy that PBMCs were cultured for 24 h at 37°C in RPMI with 10% FCS. This procedure strongly induces expression of CCR5 on monocytes, whereas expression on lymphocytes was unchanged (data not shown).
