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. 1998 May 4;187(9):1505–1516. doi: 10.1084/jem.187.9.1505

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I-A residue β9 interacts with MBP residue 4. (a) Binding of biotinylated MBP peptides with residue 4 lysine replaced with either glutamate (4E), tyrosine (4Y), or alanine (4A) to the surface of L cells transfected with β9 mutants of I-A^u and I-A^k. Binding for each mutant is compared with MBP 4A binding to wild-type I-A^u and I-A^k (normalized to 1.0 for each allele). (b) T cell hybridoma BR4 response to the altered MBP peptides described above presented by L cells transfected with β9 mutants of I-A^u and I-A^k. T cell responses to MBP 4A were normalized to 1.0 for each allele.

I-A residue β9 interacts with MBP residue 4. (a) Binding of biotinylated MBP peptides with residue 4 lysine replaced with either glutamate (4E), tyrosine (4Y), or alanine (4A) to the surface of L cells transfected with β9 mutants of I-A^u and I-A^k. Binding for each mutant is compared with MBP 4A binding to wild-type I-A^u and I-A^k (normalized to 1.0 for each allele). (b) T cell hybridoma BR4 response to the altered MBP peptides described above presented by L cells transfected with β9 mutants of I-A^u and I-A^k. T cell responses to MBP 4A were normalized to 1.0 for each allele.