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. 1998 May 4;187(9):1403–1415. doi: 10.1084/jem.187.9.1403

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Anti–I-A^b mAb created an I-E–dependent epitope for Eα6 on splenocytes. The proliferative response of Eα6 to mAb treatment of APCs which did not (A) or did (B and C) express endogenous ligand is shown. No synthetic peptide was added to this experiment. 107.1 is a B6 mouse which expresses an Eα transgene. The APCs were cultured with mAb for 30–60 min at 37°C and then T cells were added. The mixture was then cultured for 48–60 h and pulsed overnight with 1 μCi per well of [³H]thymidine, as with a proliferation assay to test the response to synthetic peptide.