Figure 1.
Effect of thalidomide on mean proliferative responses of PBMCs from three healthy donors stimulated with 10 μg/ml immobilized anti-CD3. PBMCs (105/well) were cultured in triplicate at the indicated concentrations of thalidomide. [3H]Thymidine incorporation was measured for the last 12 h of 120-h cultures. Results are expressed as mean±SD. 100% activity on the y axis represents [3H]thymidine incorporation in the absence of thalidomide (DMSO-treated control).