Table 1.
Outgrowth of Clonal B Cell Populations in C3H-lpr, C3H-gld, and BALB-gld Mice
| Strain | Age Range | Number of mice | IgH and IgL gene rearrangements | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mono- or biclonal* | Oligoclonal‡ | None§ | ||||||||
| mo | ||||||||||
| BALB-gld | 4–8 | 12 | 2 | 3 | 7 | |||||
| 9–15 | 46‖ | 26 | 13 | 4 | ||||||
| BALB+/+ | 10–21 | 22 | 0 | 0 | 22 | |||||
| C3H-gld | 4–8 | 9 | 0 | 0 | 9 | |||||
| 11–15 | 68 | 19 | 10 | 39 | ||||||
| C3H-lpr | 11–15 | 25 | 8 | 4 | 14 | |||||
| C3H+/+ | 11–15 | 25 | 0 | 0 | 25 | |||||
Spleen and LN cell DNA with ≤4 prominent rearranged clonal IgH and IgL bands.
Spleen and LN cell DNA with >4 rearranged IgH and IgL bands.
No detectable clonal rearrangements.
Three mice had rearranged IgH bands without detectable rearranged IgL bands.