Table 2.
Tumor Surface and Secreted Ig Isotypes
| Tumor | Surface Ig* | Secreted Ig‡ | Myc/Pvt 1 rearrangements§ | |||
|---|---|---|---|---|---|---|
| C3H-gld | ||||||
| 142 | IgG2a | IgG2a | ND‖ | |||
| 205 | Null | IgG2a | ND | |||
| 217 | IgG3 | IgG3 | ND | |||
| 221 | Null | IgA | ND | |||
| 223 | IgG3 | IgG3 | ND | |||
| 355 | Null | IgG2a | ND | |||
| 362 | Null | IgG3 | ND | |||
| BALB-gld | ||||||
| 208 | IgG1 | IgG1 | ND | |||
| 311 | Null | IgG3 | ND | |||
| 329 | IgM | IgM | ND | |||
| 421 | IgM | IgM | ND | |||
| 424 | IgA | IgA | ND | |||
| 425 | IgG2a | IgG2a | ND | |||
| 426 | IgA | IgA | ND | |||
| 536 | IgA | IgA | ND | |||
| 540 | IgG2a | IgG2a | ND |
*
Surface Ig expression on scid-passaged tumor cells determined by FACS® analysis.
‡
Isotype of secreted Ig in sera from tumor-bearing scid mice determined by ELISA assay.
§
Rearrangement of Myc and Pvt1 loci determined by Southern blot analysis of genomic DNA from scid-passaged tumors.
‖
ND, not detected. Rearrangements of Myc or Pvt1 were not detected.