Table 1.
Effect of 4-week treatment with various extracts and fractions of C. sinensis on body weight (g) and urine sugar in normal and STZ induced diabetic rats.
| Group | Duration of treatment and body weight |
Urine sugar | ||
|---|---|---|---|---|
| Day 1 | Day 14 | Day 28 | ||
| Untreated (+) control | 290.12 ± 3.5 | 316.90 ± 3.7 | 332.82 ± 4.3 | — |
| Diabetic (–) control | 280.33 ± 3.2# | 265.70 ± 2.9# | 262.73 ± 3.1# | +++# |
| Diabetic + tolbutamide | 304.65 ± 4.1** | 317.20 ± 4.2*** | 324.95 ± 4.3** | +** |
| Diabetic + 80% EtOH extract | 274.35 ± 2.3* | 280.62 ± 2.4* | 283.55 ± 2.4* | +* |
| Diabetic + H2O extract | 266.20 ± 2.2 | 269.50 ± 2.3 | 272.00 ± 2.2 | ++ |
| Diabetic + EaF | 310.85 ± 4.2** | 319.75 ± 4.4** | 326.95 ± 4.3** | +** |
| Diabetic + BtF | 283.41 ± 3.1* | 293.62 ± 3.2* | 296.01 ± 3.3* | +* |
All values are expressed as mean ± S.E.M. (n = 6) except for urine sugar. Diabetic control was compared with untreated control and extracts/fractions were compared with the diabetic control. *p<0.05, **p<0.01, #p<0.001. Urine sugar (+) indicates is equal or less than 0.25%; (++) indicates more than 2% and (+++) indicates more than 5% sugar. EaF: ethylacetate fraction of C. sinensis 200 mg kg−1 day−1 p.o. for 28 days. BtF: butanol fraction of C. sinensis 200 mg kg−1 day−1 p.o. for 28 days. Tolbutamide: 25 mg kg−1 day−1 p.o. for 28 days.