Table 1.
. Phenotypes of Mice Made Genetically Deficient in TNF Ligand/Receptor Family Members
| Family Members | ltα −/− | ltβ −/− | tnfα −/− | tnfr1 −/− | ltα +/− ltβ +/− | ltβ −/− tnfr1 −/− | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Spleen | ||||||||||||
| Primary B cell follicles | − | − | − | − | + | ND | ||||||
| Marginal zone | − | − | + | + | +/− | ND | ||||||
| Germinal centers | − | − | − | − | + | ND | ||||||
| Follicular dendritic cells | − | − | − | − | + | ND | ||||||
| MLNs | − | + | + | + | + | − | ||||||
| Primary B cell follicles | +/− | ND | − | + | ||||||||
| Germinal centers | +/− | ND | − | + | ||||||||
| Follicular dendritic cells | − | ND | − | + | ||||||||
| Cervical LN | − | +/−− | + | + | + | − | ||||||
| Inguinal LN | − | − | + | + | +/− | − | ||||||
| Other LN | − | − | + | + | + | − | ||||||
| PPs | − | − | +/− | +/− | − | − |
This table is based on citations in the text and others as summarized elsewhere (8), as well as the findings from this study. Unlike ltα +/− ltβ +/− double heterozygous mice, ltα +/− mice and ltβ +/− mice have PPs as well as all LNs. Other features of the phenotype of ltα +/− mice and ltβ +/− mice have not been determined. Also, although ltβ −/− tnfr1 −/− mice do not have MLNs, ltβ −/− tnfr2 −/− mice do.