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. 1998 Dec 7;188(11):1993–2005. doi: 10.1084/jem.188.11.1993

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Evolution of the Vβ8.1 spectratypes under conditions of clonal exhaustion by high doses of LCMV clone 13 infection. (A) Continuous change from days 7 to 13 in Vβ8.1 spectratypes was detected in high dose LCMV clone 13 infection. The representative CDR3 profiles from the PB of four LCMV clone 13–infected mice are displayed. (B) Loss of skewed Vβ8.1 spectratypes was detected after long term clone 13 infection. The representative CDR3 profiles from the PB of two LCMV clone 13–infected mice are displayed. The PCR products were subjected to run-off reactions using fluorescent Jβ primers.

Evolution of the Vβ8.1 spectratypes under conditions of clonal exhaustion by high doses of LCMV clone 13 infection. (A) Continuous change from days 7 to 13 in Vβ8.1 spectratypes was detected in high dose LCMV clone 13 infection. The representative CDR3 profiles from the PB of four LCMV clone 13–infected mice are displayed. (B) Loss of skewed Vβ8.1 spectratypes was detected after long term clone 13 infection. The representative CDR3 profiles from the PB of two LCMV clone 13–infected mice are displayed. The PCR products were subjected to run-off reactions using fluorescent Jβ primers.