Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1998 Dec 7;188(11):2033–2045. doi: 10.1084/jem.188.11.2033

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Induction of the CD95L by cytostatic drugs with different mechanisms of action. Semiquantitative PCR analysis of CD95L mRNA expression in HepG2, Hep3B, and Huh7 cells upon treatment with cyclophosphamide (cyclo), 5-fluorouracil (5-FU), doxorubicin (doxo), mitomycin (mitom), mitoxantrone (mitox), and actinomycin (actino). CD95L mRNA expression was induced in HepG2 (wt p53), Hep3B (p53^−/−), and Huh7 cells (mt p53). Densitometry was performed to analyze CD95L expression in relation to β-actin expression. CD95L mRNA induction was independent of the p53 status of the cells. The extent of CD95L expression upon chemotherapeutic treatment showed variability dependent on the agent and the cell line tested.