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. 1998 Dec 7;188(11):2033–2045. doi: 10.1084/jem.188.11.2033

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Restitution of a wt p53 status restores the ability of the p53^−/− cell line Hep3B to increase the CD95 receptor upon anticancer treatment (FACS^® analysis). Transient transfection of p53^−/− Hep3B cells with wt p53. Either a wt p53 expression plasmid in which expression of the p53 gene is under the control of the CMV promoter, or the corresponding control plasmid without the p53 insert (mock) was transiently transfected into Hep3B cells. Upon transient transfection with wt p53 cDNA and bleomycin treatment, p53^−/− Hep3B cells increased CD95 receptor expression.