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. 1998 Dec 7;188(11):2099–2111. doi: 10.1084/jem.188.11.2099

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Inhibition of actin polymerization blocks peptide-specific thymocyte apoptosis. (A) The actin polymerization inhibitor CytD blocks peptide-specific apoptosis of P14 TCR Tg vav ^+/+ thymocytes induced by different concentrations of the high-affinity p33 peptide. The percentage of viable CD4⁺CD8⁺ cells remaining after treatment is shown on the y-axis. Peptide concentrations are indicated on the x-axis and range from 10⁻⁶ to 10⁻⁹ M. The concentrations of CytD used to inhibit thymocyte apoptosis are indicated. (B) Dose– response curve of CytD inhibition of peptide-specific apoptosis of P14 Tg vav ^+/+ thymocytes. Percent inhibition of apoptosis is shown on the y-axis. The concentration of the deleting p33 or control AV peptide was 10⁻⁹ M. Apoptosis of CD4⁺CD8⁺ thymocytes was detected as described in Materials and Methods. One result representative of six experiments is shown.

Inhibition of actin polymerization blocks peptide-specific thymocyte apoptosis. (A) The actin polymerization inhibitor CytD blocks peptide-specific apoptosis of P14 TCR Tg vav ^+/+ thymocytes induced by different concentrations of the high-affinity p33 peptide. The percentage of viable CD4⁺CD8⁺ cells remaining after treatment is shown on the y-axis. Peptide concentrations are indicated on the x-axis and range from 10⁻⁶ to 10⁻⁹ M. The concentrations of CytD used to inhibit thymocyte apoptosis are indicated. (B) Dose– response curve of CytD inhibition of peptide-specific apoptosis of P14 Tg vav ^+/+ thymocytes. Percent inhibition of apoptosis is shown on the y-axis. The concentration of the deleting p33 or control AV peptide was 10⁻⁹ M. Apoptosis of CD4⁺CD8⁺ thymocytes was detected as described in Materials and Methods. One result representative of six experiments is shown.