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. 1998 Nov 16;188(10):1907–1916. doi: 10.1084/jem.188.10.1907

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Hematoxylin and eosin–stained ileal sections of rabbits infected with REPEC O103 (A), AAF004 (B), AAF005 (C), and PBS inoculation (D). Note the extensive villous blunting, epithelial cell necrosis and sloughing, and inflammation within the lamina propria of the wild-type infected tissue (A). In contrast, villous architecture and extent of inflammation within the lamina propria infected with AAF004 (EspA⁻) or AAF005 (EspB⁻) are similar to those of control animals that were inoculated PBS. Bar, 100 μm.