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. 1998 Nov 16;188(10):1775–1784. doi: 10.1084/jem.188.10.1775

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Serum anti-Fx1A Ab IgG isotype switching and subclass production in HN were not altered by CD8⁺ T cell depletion. IgG subclasses were detected in similar proportions at 4 and 8 wk in CD8-depleted HN, ATx/HN, and normal HN groups. CFA controls did not mount an Fx1A Ab response. At 4 wk, only the Th2-mediated IgG1 response was significantly raised above controls. By 8 wk the IgG1 response had increased further, and a significant Th1 mediated IgG2a response was identified compared with CFA controls. There was no significant-IgG2b response. Values represent mean ± SEM (n = 5) of anti-Fx1A Ab levels, expressed as percentage binding of known strongly positive serum (Fx1A Ab titer 1:250), measured by ELISA. *P < 0.005 for comparisons between CFA controls and all other groups. ANOVA followed by Bonferroni-Dunn post hoc multiple comparisons test.