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. 1998 Nov 16;188(10):1775–1784. doi: 10.1084/jem.188.10.1775

Figure 6.

Figure 6

At 2 wk, CD8+ T cell depletion did not prevent an increase in the weight of immunized popliteal LNs. (a) There was a significant increase in the weight of all immunized (CFA control, normal HN, early CD8-depleted HN) compared with unimmunized LNs, with LNs from normal HN group being the heaviest. LNs from the early CD8+ T cell– depleted group did not differ significantly from CFA controls or normal HN. Values represent the mean ± SEM (n = 4) of popliteal LN weight in grams. (b) There was a significant decrease in the proportion of B cells (OX-33+), and an increase in CD3+ T cells (G4.18+), which included both CD4+CD3+ (OX-35+G4.18+) and CD8+CD3+ (OX-8+G4.18+) cells. There were virtually no CD8+CD3+ (OX-8+G4.18+) cells present in the early CD8+ T cell–depleted group. Appropriate reciprocal changes to CD8+ T cell–depleted LNs were seen in LNs from the other groups. Values represent the mean ± SEM (n = 4) of labeled lymphocytes as percentage of total gated population identified by FACS® analysis. *P < 0.01, **P < 0.001, ***P < 0.0001. ANOVA followed by Bonferroni-Dunn post hoc multiple comparisons test.