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. 1998 Nov 16;188(10):1775–1784. doi: 10.1084/jem.188.10.1775

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At 2 wk, CD8⁺ T cell depletion did not alter the balance of Th1 and Th2 cytokine expression in LNs from rats with HN. Immunization with CFA and CFA/Fx1A resulted in significantly increased expression of Th1, Th2, and cytotoxic cell cytokines when compared with unimmunized LNs. This was not significantly decreased by CD8⁺ T cell depletion. Cytotoxic cell molecules in rats depleted of CD8⁺ T cells were probably from NK cells. Results are expressed as the median cycle number (n = 4) at which PCR product was first detected, measured at five-cycle intervals. *P < 0.01, **P < 0.001. U, PCR product undetectable. ANOVA followed by Bonferroni-Dunn post hoc multiple comparisons test.