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. 1998 Dec 21;188(12):2205–2213. doi: 10.1084/jem.188.12.2205

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GP33-specific CD8 T cells in chronically infected CD4^−/− mice are activated and proliferate, but are refractive to stimulation with PMA and ionomycin. (A) CD69 expression on freshly explanted splenocytes from +/+ and CD4^−/− mice at 78 d after infection was assessed using flow cytometry. (B) IFN-γ production by GP33-specific CD8 T cells after PMA and ionomycin stimulation. Splenocytes were isolated from +/+ and CD4^−/− mice at 108 d after infection with LCMV-t1b. (C) The in vivo proliferation of GP33-specific CD8 T cells in LCMV-t1b infected +/+ and CD4^−/− mice (day 100 after infection) was assessed by in vivo BrdU labeling. Mice were fed BrdU in their drinking water for a total of 8 d. All histograms show D^b(GP33–41)-positive cells and the percentage of GP33-specific T cells within each region is indicated.