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. 1998 Dec 21;188(12):2313–2320. doi: 10.1084/jem.188.12.2313

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Heat-labile serum factor(s) augment the phagocytosis of apoptotic cells in a concentration-, time-, and temperature-dependent fashion. (A) Apoptotic murine thymocytes were offered to human macrophages in the presence of 15% normal non– heat-inactivated human serum (NHS), 15% normal heat-inactivated (56°C for 30 min) serum (HIS), or without (NoS) the addition of serum, as described in Materials and Methods. The results are expressed as PI, and the mean ± SD of five experiments is shown. (B) Phagocytosis of apoptotic cells was compared at 4°C and 37°C. (C–G) Wright stain of human macrophages after exposure to either murine apoptotic thymocytes (C and D) or autologous human apoptotic neutrophils (E–G) in the presence (C, F, and G) or absence (D and E) of 15% human serum. Original magnification: ×400. Arrows, some of the apoptotic cells bound or engulfed.

Heat-labile serum factor(s) augment the phagocytosis of apoptotic cells in a concentration-, time-, and temperature-dependent fashion. (A) Apoptotic murine thymocytes were offered to human macrophages in the presence of 15% normal non– heat-inactivated human serum (NHS), 15% normal heat-inactivated (56°C for 30 min) serum (HIS), or without (NoS) the addition of serum, as described in Materials and Methods. The results are expressed as PI, and the mean ± SD of five experiments is shown. (B) Phagocytosis of apoptotic cells was compared at 4°C and 37°C. (C–G) Wright stain of human macrophages after exposure to either murine apoptotic thymocytes (C and D) or autologous human apoptotic neutrophils (E–G) in the presence (C, F, and G) or absence (D and E) of 15% human serum. Original magnification: ×400. Arrows, some of the apoptotic cells bound or engulfed.