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. 1998 Dec 21;188(12):2233–2241. doi: 10.1084/jem.188.12.2233

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TSA restores rearrangement of the TCR-γ locus in IL-7Rα^−/− thymocytes. Bone marrow from IL-7R^−/− mice was used to reconstitute irradiated embryonic thymic lobes (from C57BL/6 mice) in hanging drops. Reconstituted lobes were then cultured in the indicated concentrations of TSA for 96 h and analyzed for rearrangement of the TCR-γ locus.