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. 1998 Dec 21;188(12):2289–2299. doi: 10.1084/jem.188.12.2289

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IL-4 production by CD4-enriched spleen cell populations. Spleen cells from BALB/c (H-2^d), BALB.B (H-2^b), BALB.K (H-2^k), and B10.D2 (H-2^d) mice were depleted of CD8⁺ T cells and were activated with anti-TCRβ and anti-CD28 mAbs in the presence of IL-2, and in the absence (left) or presence (right) of anti–IL-4 mAb. After 5 d, cells were restimulated with fresh APCs, anti-TCRβ mAb, and IL-2. After 48 h, the supernatants were harvested and analyzed for IL-4 by ELISA. Results depict means ± SEM of triplicate determinations. C57BL/6 cells gave results comparable to B10.D2 cells.