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. 1998 Dec 21;188(12):2215–2224. doi: 10.1084/jem.188.12.2215

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Similar proliferation of IA7 and BALB/c bone marrow B cell subsets. To determine the fraction of cycling bone marrow B cells, nine BALB/c and eight IA7 littermates were fed with BrdU for 2 d. Bone marrow cells were analyzed flow cytometrically by acquiring 3 × 10⁴ cells stained for B220 and IgM as described in the legend to Fig. 2, and after permeabilization with an FITC-labeled anti-BrdU antibody. In both groups of mice pre-B (IgM⁻ B220^low), immature (IgM⁺ B220^low) BALB/c, and mature (IgM⁺/low B220^high) bone marrow B cells incorporated similar amounts of BrdU, indicating comparable proliferation rates. Similar results were obtained when we used ID4 instead of IA7 transgenic mice.