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. 1998 Jul 20;188(2):305–315. doi: 10.1084/jem.188.2.305

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Effects of various enzymes that lyse PepG on the nitrite formation induced by PepG (10 μg/ml) plus IFN-γ (10 IU/ml) in macrophages at 24 h. The muramidases, mutanolysin and M1, attenuated significantly the nitrite formation caused by PepG plus IFN-γ. In contrast, lysozyme, a muramidase that does not lyse the PepG from S. aureus, did not affect this response. The endopeptidase lysostaphin significantly enhanced the nitrite formation, whereas SALE, which has both endopeptidase and amidase activities, completely prevented the nitrite formation. Data are expressed as means ± SE of 9–12 wells from three to four independent experiments. *P <0.05 versus PepG plus IFN-γ control response.