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. 1998 Jul 20;188(2):305–315. doi: 10.1084/jem.188.2.305

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Effects of various fragments of PepG in the presence of (A) IFN-γ or (B) LTA (from S. aureus) on the nitrite accumulation in the supernatant of macrophages. The PepG fragments NAG-NAM-l-ala-d-isoglutamine (A, circles; B, 1 μg/ml) and NAM-l-ala-d-isoglutamine (A, squares; B, 1 μg/ml) concentration-dependently synergized with IFN-γ (10 IU/ml) or LTA (0.1 μg/ml) to cause nitrite accumulation. The NAM-l-ala-L-isoglutamine fragment (A, triangles; B, 1 μg/ml) was less effective, whereas the fragment NAM-D-ala-d-isoglutamine (A, diamonds; B, 100 μg/ml) was inactive in synergizing with IFN-γ or LTA. Data are expressed as means ± SE of 9–12 wells from three to four independent experiments. LTA (0.1 μg/ml) produced 15 ± 1 μM at 24 h.