Table 1.

Extent of the Pulmonary Inflammatory Process of TCR-transgenic Mice Infected with Influenza A Virus

Mice		Virus		Time after infection
				Day 2		Day 5		Day 8		Day 15		Day 20
F5–RAG-1−/−		A/NT/60/68, 107 PFU		+		++		++		*
		A/NT/60/68, 102 PFU		−		+		+		±		±
		X31, 107 PFU		+		++		++		*
RAG-1−/−		A/NT/60/68, 107 PFU		±		+		++		++		++
		X31, 107 PFU		+		++		++		*

++, Intensive pathology with cell inflammation encompassing several segments of lung tissues. Development of extensive lung edema and congestion. Thickened intraalveolar septa and loss of alveoli. +, Inflammatory reaction consisting of a few foci of peribronchiolar and perivascular infiltrates on medium and small airways. There was modest evidence of epithelial necrosis of affected tracheobronchiolar mucosa. ±, Lung tissue with a few infiltrates. No epithelial necrosis or desquamation. −, Lung tissue well aerated. No infiltrates or pathologic alteration of lung tissue.  

^*, At the indicated time, all mice had died.