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Aβ-mediated complement activation generates C5a and the MAC. (a) Preaggregated Aβ 1–42 was incubated in NHS, and C5a generation was then quantitated as described in Materials and Methods. (b) C5b-9 was quantitated after NHS was incubated with varying concentrations of preaggregated Aβ 1–42 or 1–40. SC5b-9 formation was quantitated as described in Materials and Methods.
