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. 1998 Aug 3;188(3):609–614. doi: 10.1084/jem.188.3.609

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Lysis by HIV-1–specific CTLs is mediated by CCR3. Transformed autologous B cells infected with recombinant vaccinia virus expressing Gag were used as target cells. Lysis by HIV-1–specific CTL lines obtained from two individuals (A and B) was determined at an E/T ratio of 120:1 in the presence of different chemokines (all 25 nM), 25 nM RANTES(9-68), 1 μg/ml anti-RANTES, 1 μg/ml anti-CCR3, 1 μg/ml anti-CCR3 plus 25 nM RANTES, or without additions. Similar effects were obtained in eight experiments with CTLs from different HIV-1–infected donors.