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. 1998 Aug 3;188(3):609–614. doi: 10.1084/jem.188.3.609

Figure 4.

Figure 4

(Top) RANTES enhances the CTL activity of freshly isolated PBMCs. The lytic activity of PBMCs obtained from two HIV-1– infected individuals (A and B) was assayed at an E/T ratio of 120:1 against transformed autologous B cells infected with recombinant vaccinia virus expressing Pol (A) and Gag (B) in the presence of 25 nM RANTES, 1 μg/ml anti-RANTES, 1 μg/ml anti-CCR3, 1 μg/ml anti-CCR3 plus 25 nM RANTES, or without additions. (Middle and bottom) RANTES activity is mediated by MHC-restricted CD8+ T cells. HIV-1–specific lysis by CTL lines derived from the PBMCs of the same patients (A and B) was determined against autologous and mismatched transformed B cells infected with recombinant vaccinia virus expressing Pol (A) and Gag (B) in the presence of 25 nM RANTES, 1 μg/ml anti-RANTES, 1 μg/ml anti-CD8, 1 μg/ml anti-CD8 plus 25 nM RANTES, or without additions.