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. 1998 Oct 5;188(7):1381–1384. doi: 10.1084/jem.188.7.1381

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TNF-induced JNK and NF-κB activation are mediated by distinct signal transduction pathways. (Top) Cell lysates prepared from thymocytes unstimulated (−) or stimulated (+) with TNF (10 ng/ml) for 2.5 min were used to measure JNK activity by immunocomplex kinase assay with GST–c-Jun(1-79) as a substrate. (Bottom) Nuclear extracts (4 μg) prepared from thymocytes unstimulated (−) or stimulated (+) with TNF for 15 min were used in gel-shift assays of NF-κB/Rel binding activity.