Table 2.
Models | Predicted fraction in-frame | Experimental data | Observed percentage in frame | |||
---|---|---|---|---|---|---|
Perfect feedback regulation with functional κ chain preventing λ rearrangement | 0% | 27 out of 57 VκJκ-intron-RS loci | 47.4% (P < 0.04) | |||
Poor feedback regulation | ≤33% | |||||
High frequency of Vκ pseudogenes | ≤33% | |||||
High frequency of H/κ chain mispairing | ≤33% | |||||
Any combination of the above | ≤33% | |||||
Extreme model of editing with random RS rearrangements and all κs autoreactive | 33% |