Figure 2.

Progesterone inhibits [Ca²⁺]_i oscillations induced by TCR ligation. (A) [Ca²⁺]_i responses from four representative B3Z cells activated by contact with SIINFEKL-presenting K897 cells illustrate that [Ca²⁺]_i oscillations were reversibly inhibited by the application of 50 μM progesterone to the bath (bar). (B) [Ca²⁺]_i oscillations in four B3Z cells activated by settling onto coverslips coated with anti–CD3-ε antibodies in the absence (a) or presence (b) of 50 μM progesterone.