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. 1998 Nov 2;188(9):1593–1602. doi: 10.1084/jem.188.9.1593

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Progesterone reduces the [Ca²⁺]_i plateau evoked by TG stimulation in human T cells. (A) Average [Ca²⁺]_i is plotted against time (n = 76) before and during stimulation with 1 μM TG (arrow). TG stimulated Ca²⁺ influx, resulting in a stable rise in [Ca²⁺]_i. Addition of 30 μM progesterone (bar) reversibly reduced the [Ca²⁺]_i plateau obtained after TG stimulation. (B) The concentration dependence of the reduction of [Ca²⁺]_i by progesterone is plotted for TG-stimulated cells. Calcium levels were normalized by subtracting the resting [Ca²⁺]_i and dividing [Ca²⁺]_i in the presence of progesterone and TG by [Ca²⁺]_i in the presence of TG alone. Data are presented as mean ± SD and were fitted to a Hill equation illustrated by the smooth curve (IC₅₀ = 28 ± 2.7 μM and n = 1.3 ± 0.2).

Progesterone reduces the [Ca²⁺]_i plateau evoked by TG stimulation in human T cells. (A) Average [Ca²⁺]_i is plotted against time (n = 76) before and during stimulation with 1 μM TG (arrow). TG stimulated Ca²⁺ influx, resulting in a stable rise in [Ca²⁺]_i. Addition of 30 μM progesterone (bar) reversibly reduced the [Ca²⁺]_i plateau obtained after TG stimulation. (B) The concentration dependence of the reduction of [Ca²⁺]_i by progesterone is plotted for TG-stimulated cells. Calcium levels were normalized by subtracting the resting [Ca²⁺]_i and dividing [Ca²⁺]_i in the presence of progesterone and TG by [Ca²⁺]_i in the presence of TG alone. Data are presented as mean ± SD and were fitted to a Hill equation illustrated by the smooth curve (IC₅₀ = 28 ± 2.7 μM and n = 1.3 ± 0.2).