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. 1998 Nov 2;188(9):1705–1715. doi: 10.1084/jem.188.9.1705

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Increased numbers of IFN-γ–secreting (A) CD8⁺ and (B) CD4⁺ T cells in the peritoneum of LCMV-immune mice challenged with VV (Day 3). Peritoneal cells were harvested from age-matched naive and LCMV-immune C57BL/6 mice challenged with purified VV at day 3 of infection or from LCMV-immune mice challenged with control purified cell supernatant (day 3). The total number of CD8⁺ and CD4⁺ cells (cross-hatched bars) and total number of IFN-γ secreting CD8⁺ and CD4⁺ cells (solid bars) was determined as described in Materials and Methods. *Represents a statistically significant difference from the LCMV-immune+VV group (P < 0.01).