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. 1998 Sep 21;188(6):1039–1046. doi: 10.1084/jem.188.6.1039

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The biphasic, serum-dependent effect of recombinant IL-4 on the migration of capillary endothelial cells. (A) Serum-starved bovine adrenal capillary endothelial cells were allowed to migrate towards murine IL-4 in the absence (circles) or in the presence (triangles) of an inducing concentration of bFGF. Identical results were obtained using recombinant human IL-4. (B) IL-13 tested as was IL-4 in A. (C) Serum-starved human dermal capillary endothelial cells were allowed to migrate towards murine IL-4 (open symbols) or towards human IL-4 (filled symbols) in the absence (circles) or presence (triangles) of bFGF. Note: In all graphs, dotted lines indicate migration seen towards vehicle (0.1% bovine serum albumin, BSA) or towards 10 ng/ml bFGF (bFGF); bars indicate SE.

The biphasic, serum-dependent effect of recombinant IL-4 on the migration of capillary endothelial cells. (A) Serum-starved bovine adrenal capillary endothelial cells were allowed to migrate towards murine IL-4 in the absence (circles) or in the presence (triangles) of an inducing concentration of bFGF. Identical results were obtained using recombinant human IL-4. (B) IL-13 tested as was IL-4 in A. (C) Serum-starved human dermal capillary endothelial cells were allowed to migrate towards murine IL-4 (open symbols) or towards human IL-4 (filled symbols) in the absence (circles) or presence (triangles) of bFGF. Note: In all graphs, dotted lines indicate migration seen towards vehicle (0.1% bovine serum albumin, BSA) or towards 10 ng/ml bFGF (bFGF); bars indicate SE.