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. 2007 Sep 7;9(5):R87. doi: 10.1186/ar2286

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Copyright © 2007 Fasth et al., licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CD4⁺CD28^nullT cells from peripheral blood and synovial fluid show human cytomegalovirus specificity. (upper panel) The functional capacity of CD4⁺CD28^nullT cells in peripheral blood (PB) and synovial fluid (SF) was investigated after stimulation of mononuclear cells from paired PB and SF from rheumatoid arthritis patients by plate-bound anti-CD3 antibodies. (lower panel) The reactivity of CD4⁺CD28^nullT cells in paired PB and SF to human cytomegalovirus (HCMV) antigens was analysed after stimulation by the pp65 or immediate early (IE) antigens.