Table 5.
Treatments for non-infectious scleritis.
| Antimetabolites | T cell inhibitors | Alkylating agents | Biologics |
|---|---|---|---|
| Methotrexate*
(start 15 mg weekly) (max 25 mg weekly) |
Cyclosporine**
(start 2 mg/kg twice daily) (max 2.5 mg/kg twice daily) |
Cyclophosphamide†
(start up to 2 mg/kg daily) (max 200 mg/daily) |
Infliximab**
(start 5 mg/kg every 6 weeks) (max 10mg/kg every 4 weeks) |
| Azathioprine
(start 2 mg/kg daily) (max 200 mg daily) |
Tacrolimus
(start 1 mg twice daily) (increase dose until therapeutic) |
Chlorambucil
(start 0.1 mg/kg daily) (max 12 mg/daily) |
Rituximab
(optimal dose uncertain) |
| Mycophenolate mofetil*
(start 1 gram twice daily) (max 1.5 gram twice daily) |
*
First line treatment in cases where inability to control disease on desired prednisone dose. Generally start for active disease on ≥10 mg prednisone/day
†
First line agent in cases of systemic vasculitis
**
Second line agents added if maximal tolerated dose of antimetabolite alone does not allow for control of disease on desired prednisone dose.