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. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: Biomaterials. 2007 Aug 13;28(34):5185–5192. doi: 10.1016/j.biomaterials.2007.07.044

Figure 4.

Figure 4

(A) Self-assembly of HPMA graft copolymers, CCK-P and CCE-P, containing oppositely charged peptide grafts (P is the HPMA copolymer backbone; see Figure 2 for structure of CCE and CCK). Aqueous solutions of CCE-P or CCK-P did not form gels. In contrast, gel-like materials were formed from equimolar mixtures of CCE-P/CCK-P at low concentrations. (B) pH dependence of the secondary structure of CCE, CCK, and equimolar mixture CCE/CCK expressed as the content of α-helix. (C) Microrgeology of 1% w/v solutions of CCE-P, CCK-P, and equimolar mixture of CCE-P/CCK-P. Mean square displacement of tracking particles as a function of time. (D) CD spectra of the equimolar mixture CCK-P/CCE-P before (full tilted squares) and after (empty triangles) denaturation by guanidine hydrochloride at 25 °C at a 20 µM peptide concentration and after removal of guanidine hydrochloride by dialysis (empty squares). Adapted from [10].