Time dependence of mole fractions γN, γI, and γD of holo- (solid lines), and apo- (dotted lines) forms of CP at 37°C. The kinetics were obtained from Eq. 5 using the average parameters from DSC experiments; i.e., for the holo- form (Ea,1 = 254 kJ/mol, T1* = 334 K, Ea,2 = 227 kJ/mol, T2* = 352 K): k1 = 8.0 × 10−4 min−1, and k2 = 2.8 × 10−5 min−1; and for the apo- form (Ea,1 = 254 kJ/mol, T1* = 330 K, Ea,2 = 308 kJ/mol, T2* = 333 K): k1 = 2.7 × 10−3 min−1, and k2 = 2.5 × 10−4 min−1, respectively.