Figure 1.

Amino acid sequence of EPO-R domain with homology to MHC-I peptide D^k-(61–85). To identify the most similar sequence to MHC-I peptide D^k-(61–85) in EPO-R, we used bestfit (GCG Software Package version 8.0 with default parameters: rescaled PAM250 matrix, gap creation penalty 3.00, gap extension penalty 0.10) as in our previous paper (1). Output of bestfit is shown as the 23-mer aligned underneath the MHC-I peptide. Location of the homologous sequence in EPO-R is indicated at left, numbering according to precursor receptor protein, as per Swissprot data bank. Traditional numbering of D^k-(61–85) is for mature protein; Swissprot numbering is 85–109. Black boxes, identity; gray boxes, similarity. Identity 24%, similarity (including identity) 40%.