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. 2007 Oct 19;94(4):1169–1184. doi: 10.1529/biophysj.107.116798

FIGURE 1.

FIGURE 1

The geometry of the model RyR pore. In the experiments and calculations, the lumen of the sarcoplasmic reticulum (SR) is electrically grounded. The circle around each labeled amino acid is meant to illustrate the range of the motion of the terminal carboxyl group. Aspartates (solid circles) are given a radius of 5 Å and glutamates (dashed circles) 7 Å. Only the amino acids of one of the four identical RyR subunits is shown. Asp-4945, Asp-4938, Asp-4899, Glu-4900, and Glu-4902 are the only amino acids explicitly modeled in the theory. The GGGIG sequence (4894–4898 in the numbering) at the cytosolic end of the selectivity filter is only a reference point for readers familiar with the RyR sequence.