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. 2007 Oct 19;94(4):1241–1251. doi: 10.1529/biophysj.107.117796

FIGURE 3.

FIGURE 3

Modulation of Kv4.2:KChIP-1 channels by external permanent ions. (A) The overlay of traces at +50 mV in the presence of 132 mM K+ (black trace) or 132 mM of the test monovalent cation as indicated (gray trace). (B) Inactivation time constants versus permeability ratio. Permeability ratios under bionic conditions were calculated by applying the Goldman-Hodgkin-Katz equation (1). (C) Time constants of inactivation at +70 mV against concentration of external K+. Solid line is the best-fit Hill equation with the apparent equilibrium dissociation constant (KD) of 8 mM and a Hill coefficient, nH = 1. Inset shows normalized currents at +70 mV obtained by application of various external K+ concentration (0, 2, 5, 15, 50, and 132 mM). Note the gradual acceleration of the development of inactivation upon raising external [K+].