FIGURE 7.

Sequential detachment of FAs opposite to the pulling direction leads to different morphology depending on the initial cell geometry. Each geometry is shown without (a, c, and e) and with rupture (b, d, and f). For initially circular (a and b) or elliptical cells pulled along the minor (short) axis (c and d), a morphology arises which is typical for migrating keratocytes. For initially elliptical cells pulled along the major (long) axis (e and f), we get a morphology that is typical for migrating fibroblasts.