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. 2004 Mar 15;199(6):805–814. doi: 10.1084/jem.20031454

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Copyright © 2004, The Rockefeller University Press

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Figure 3. — Sclerostin protein is not expressed by osteoclasts in mouse and human bone. Goldner staining of a rib of a 17.5-d-old fetal mouse embryo (A). Specific SOST mRNA expression in mineralized bone of the rib using antisense probe against SOST (B). TRAcP staining of the rib showing that osteoclasts do not colocalize with SOST mRNA expression. TRAcP⁺ osteoclasts (arrowheads) are present in the bone marrow and on the surface of the bone collars, whereas SOST mRNA is located within the bone collar (C). Sclerostin staining of human bone biopsy of a 12-yr-old girl shows that sclerostin is expressed by osteocytes, but not by multinuclear osteoclasts on the bone surface (D). TRAcP staining to identify multinuclear osteoclasts on the bone surface (E). Magnification is (A and B) 100 and (C–E) 200.