Figure 6.
Persistence of protection after a heterologous MVA-PyCS boost. Groups of five mice were primed with 105 17D-Py and boosted 2 wk later i.v. with 107 PFU of MVA-PyCS. The groups of mice were challenged with sporozoites between 2 and 16 wk after the boost. Results are expressed as the mean ± SE of five mice per group. (A) Inhibition of development of parasite liver stages. (B) Number of IFNγ-secreting spleen cells after in vitro stimulation with the P. yoelii CS CD8+ T cell epitope.