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. Author manuscript; available in PMC: 2008 Jan 24.
Published in final edited form as: Nature. 2007 Jun 14;447(7146):799–816. doi: 10.1038/nature05874

Figure 3.

Figure 3

Overview of RACE experiments showing a gene fusion. Transcripts emanating from the region between the DONSON and ATP50 genes. A 330-kb interval of human chromosome 21 (within ENm005) is shown, which contains four annotated genes: DONSON, CRYZL1, ITSN1, and ATP50. The 5′ RACE products generated from small intestine RNA and detected by tiling-array analyses (RxFrags) are shown along the top. Along the bottom is shown the placement of a cloned and sequenced RT-PCR product that has two exons from the DONSON gene followed by three exons from the ATP50 gene; these sequences are separated by a 300-kb intron in the genome. A PET tag shows the termini of a transcript consistent with this RT-PCR product.