Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Mar 7;201(5):713–722. doi: 10.1084/jem.20042031

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — Lipidomic analysis of RvE1 in human plasma. (a) Representative MS/MS selected ion chromatogram at m/z 291 and (b) MS³ selected ion chromatogram at m/z 229. (c) Scheme of RvE1 generation from EPA. Human endothelial cells expressing COX-2 treated with aspirin transform EPA by abstracting hydrogen at C16 to give R insertion of molecular oxygen to yield 18R-H(p)EPE. Alternatively, cytochrome P450 monooxygenase can convert EPA to 18R-HEPE (reference 28). They are further converted via sequential actions of a leukocyte 5-LO–like reaction, which leads to formation of RvE1.