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. 2005 Mar 7;201(5):769–777. doi: 10.1084/jem.20041179

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Copyright © 2005, The Rockefeller University Press

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Figure 4. — The initial engraftment and proliferation of T_reg cells in neonatal lymph nodes requires IL-2. Neonatal IL-2Rβ^−/− mice were adoptively transferred with CD45.1⁺ CFSE-labeled CD4⁺CD25⁺ T cells (2 × 10⁵) and received either PBS or α-IL-2 mAb (100 μg) on the day of transfer and 3 d later. 6 d after transfer, lymph node cells from individual recipient mice were subjected to FACS analysis. (A) Histograms of donor (CD45.1) engraftment. (B) Dot plots for CD4 and CD25 expression after gating on CD45.1⁺ donor cells. (C) Histograms of proliferating donor CD4⁺CD25⁺ T cells based on CFSE staining. n = 3 per group.