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. 2005 Aug 15;202(4):541–549. doi: 10.1084/jem.20041503

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Copyright © 2005, The Rockefeller University Press

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Figure 1. — Skin-targeted transgenic expression of TSLP causes eczematous-like skin lesions accompanied by pronounced lymphadenopathy and splenomegaly. (A) RT-PCR analysis of TSLP transgene expression in the skin of a K5-TSLP mouse and a normal littermate control (NLC) after 3 wk of dox treatment. From the K5-TSLP mouse, total RNA isolated from affected lesional skin (L) and unaffected skin (U) were analyzed separately. (B) An immunohistochemical localization of TSLP in the skin of a K5-TSLP mouse as compared with NLC. TSLP in a K5-TSLP mouse was expressed in the epidermis and its basement membrane (brown). (C) Images showing a K5-TSLP mouse and NLC after 3 wk of dox treatment. Arrowheads mark eczematous lesions on the snout and trunk. Images are representative of >10 K5-TSLP mice analyzed.