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. 2005 Sep 5;202(5):637–650. doi: 10.1084/jem.20050821

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Copyright © 2005, The Rockefeller University Press

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Figure 3. — IFN-I–unresponsive CD8 T cells exhibit highly diminished expansion compared with IFN-I–responsive CD8 T cells of identical specificity in the same infected host. 60,000 each of WT (Thy1.2, Ly5.1) plus IFN-IR⁰ (Thy1.2, Ly5.2) P14 CD8 T cells were cotransferred into a congenic host (Thy1.1, B6 Ly5.2) and infected with LCMV the next day. Donor cells were analyzed on gated CD8⁺ cells in the spleen (A) and in other compartments (B) on day 8 after infection. Data are representative of two experiments with four mice in each experiment. Numbers represent the percentage of cells in the indicated quadrant.