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. 2005 Sep 5;202(5):637–650. doi: 10.1084/jem.20050821

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Copyright © 2005, The Rockefeller University Press

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Figure 7. — The difference in the expansion of WT and IFN-IR⁰ CD8 T cells in response to viral infection was observed in IFN-IR⁰ and heterozygous hosts. 35,000 each of WT (Ly5.1) and IFN-IR⁰ P14 CD8 T cells (Ly5.2) were cotransferred into littermate IFN-R^+/+, IFN-IR^+/−, or IFN-IR^−/− hosts (Ly5.2) and assessed for their expansion in response to LCMV infection. (A) The ratio of WT/IFN-IR⁰ P14 donor CD8 T cells was analyzed by gating on MHC tetramer–positive CD8 T cells and assessing Ly5.1 staining among V β8 TCR-positive cells (P14 CD8 T cells express V β8 TCR). The average recovery of IFN-R^+/− and IFN-IR^−/− P14 donor CD8 T cells per spleen is indicated in parenthesis (n = 3 per group). (B) Spleen viral titers at different times after infection. Each dot represents an individual mouse. IFN-IR expression heterozygosity was confirmed by PCR.